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Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women
Sponsor: Universidad de Almeria
Summary
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women. Participant Population/Health Conditions: The study will involve 40 young, lean adult women. Main Questions: The main questions this study aims to answer are: * Are there active brown or beige adipocytes in the subcutaneous fat of the dorsocervical area (i.e., iBAT)? * What is the secretory function of these adipocytes? * How do traditional interventions like cold exposure, as well as new approaches like Beta-2 agonist stimulation and exercise, affect the thermogenesis of these fat cells at the cellular and molecular levels? Participants Will: Be randomized into one of four groups: thermoneutral exposure, cold exposure, aerobic exercise, or Beta-2 agonist treatment. Follow their assigned regimen for 4 weeks. Provide tissue samples from the dorsocervical area and abdomen before and after the 4-week intervention. Undergo analysis of these samples using advanced techniques to understand the presence and activity of brown and beige fat cells. Comparison Group: Researchers will compare the effects of different interventions (thermoneutral exposure, cold exposure, aerobic exercise, Beta-2 agonist treatment) on the presence and thermogenesis of brown and beige fat cells in the dorsocervical area.
Official title: Deciphering the Molecular and Secretory Functions of a Novel and Unique Brown Adipose Tissue Depot in Women
Key Details
Gender
FEMALE
Age Range
18 Years - 22 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-11-01
Completion Date
2026-08
Last Updated
2024-05-23
Healthy Volunteers
Yes
Conditions
Interventions
Thermoneutral condition
Participants will be exposed 2 hours/day at 32ºC for 5 days/week
Cold condition
Participants will be exposed 2 hours/day at 18ºC for 5 days/week
Aerobic exercise condition
Participants will perform aerobic exercise training 5 days/week at 65% heart rate reserve for 60 minutes each training session
Salbutamol
Participants will take salbutamol 12 mg/day. 7 days week
Locations (1)
Universidad de Almería
Almería, Spain