Clinical Research Directory

Inclusion Criteria: 1. Age \>18 years. 2. Left ventricular ejection fraction (LVEF) \<50% within 2 years prior to planned randomization (assessed by echocardiography or MRI). 3. New York Heart Association (NYHA) class II \~ III. 4. Either hospitalization for HF within 6 months prior to planned randomization or elevated plasma levels of natriuretic peptides within 3 months of randomization. a. For patients in sinus rhythm: NT- proBNP \>300 pg/mL or BNP \>100 pg/mL. b. For patients in atrial fibrillation: NT-proBNP \>600 pg/mL or BNP \>200 pg/mL. 5. Subjects with stable CHF (NYHA II/III functional class) on optimal background therapy (as determined by the investigator) for at least 4 weeks with no dose changes of heart failure drugs during the last 2 weeks (with the exception of diuretics). 6. Serum ferritin \<100 ng/mL or serum ferritin 100-300 ng/mL and TSAT \<20%. 7. Able and willing to perform a CPET at the time of randomization. 8. Able and willing to provide informed consent. Exclusion Criteria: 1. Hemoglobin \<9.0 g/dL or Hemoglobin \>15.0 g/dL. 2. Renal dialysis or MDRD/CKD-EPI estimated glomerular filtration rate (eGFR) \<15 ml/min/1.73m2. 3. Body weight \<35 kg. 4. Heart failure was secondary to valvular diseases or congenital heart diseases. 5. History of acquired iron overload; known hemochromatosis or first relatives with hemochromatosis. 6. Known hypersensitivity to ferric derisomaltose or other IV iron product. 7. Known active infection (defined as currently treated with oral or intravenous antibiotics), bleeding (gastrointestinal hemorrhagia, menorrhagia, history of peptic ulcer with no evidence of healing or inflammatory bowel disease), malignancy, and hemolytic anemia. 8. History of chronic liver disease and/or alanine transaminase (ALT) or aspartate transaminase (AST) \>3 times the upper limit of the normal range; myelodysplastic disorder; and known HIV/AIDS disease. 9. Acute myocardial infarction, acute coronary syndrome, transient ischemic attack, or stroke within 3 months prior to randomization. 10. Revascularization therapy (coronary artery bypass grafting, percutaneous intervention, or major surgery) within 3 months prior to randomization; or planning cardiac surgery or revascularization. 11. Already receiving erythropoietin, IV or oral iron therapy, and blood transfusion in previous 30 days prior to randomization. 12. Use of concurrent immunosuppressive therapy 13. Any of the following diseases that hinders exercise testing: severe musculoskeletal disease, unstable angina, obstructive cardiomyopathy, severe uncorrected valvular disease, or uncontrolled slow or rapid arrhythmia (mean ventricular rate \>100 beats/min at rest), or uncontrolled hypertension with blood pressure \>160/100 mm Hg. 14. Investigator considers a possible alternative diagnosis to account for the patient's HF symptoms: severe obesity, primary pulmonary hypertension, or chronic obstructive pulmonary disease. 15. Pregnancy or breast feeding. 16. Participation in another intervention study involving a drug or device within the past 90 days.