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Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium. This approach is feasible on small fragments of villi and offers for the first time the possibility to consider the characterization of gene expression within the structural unit of the human placenta during pregnancy (at the 1st trimester and childbirth)
Official title: Cellular Transcriptomic Trajectory of the Human Placenta During Pregnancy
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-03-25
Completion Date
2029-02
Last Updated
2026-04-03
Healthy Volunteers
No
Conditions
Interventions
Non applicable
Placental transcriptomic analysis
Locations (1)
Maternité Port-Royal, Cochin hospital
Paris, IDF, France