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A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement
Sponsor: University of Michigan
Summary
The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new biomarker steroids to reflect adequate osilodrostat dosing, the durability and safety, and clinical improvement during treatment.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
12
Start Date
2024-07-19
Completion Date
2027-08
Last Updated
2025-08-20
Healthy Volunteers
No
Interventions
Osilodrostat
Add methylprednisolone to osilodrostat therapy after first dose and continue during osilodrostat titration.
Locations (1)
University of Michigan
Ann Arbor, Michigan, United States