Clinical Research Directory

Inclusion Criteria: 1. Voluntarily join the study and sign the informed consent; 2. Age: 18-75 years old, male or female; 3. Subjects with advanced gastric cancer who had received systematic standard treatment before enrollment and had no effective treatment at present. (Note: The effective treatment means refer to the latest version of the "Gastric Cancer Diagnosis and Treatment Guide" issued by China's "Chinese Clinical Oncology Society".) ; 4. Have at least one measurable lesion according to imRECIST evaluation criteria; 5. Expected survival ≥5 months (starting from the collection of tissue samples for sequencing); 6. The Eastern Cancer Consortium (ECOG) score was 0 or 1 or 2; 7. The following hematological indicators should be met: neutrophil count ≥ 1.5×109/L; Hemoglobin ≥ 10.0 g/dL; Platelet count ≥ 50×109/L; 8. The following biochemical indicators should be met: total bilirubin ≤2.0× upper limit of normal value (ULN); AST and ALT ≤2.0×ULN; Serum creatinine ≤1.5×ULN. 9. Before lymphocyte clearance preadministration: 1) any chemotherapy, small molecule targeted drugs and other antitumor therapy received have passed the 3-week washout period, and the toxic side effects have returned to grade 1 or lower (excluding hair loss, vitiligo and other events as determined by the investigator to be tolerated); 2) If surgical treatment is performed within 3 weeks, toxicity has returned to grade 1 or lower; 3) The immunotoxicity of major organs has returned to grade 1 or lower after receiving any antibody drug treatment, and the washout period of PD-1 antibodies has reached 6 weeks, and CTLA-4 antibodies and other antibodies have passed the washout period of 4 weeks. Exclusion Criteria: 1. Subjects infected with HBV, HCV, HIV, syphilis and tuberculosis; 2. Uncontrolled coronary artery disease or asthma, uncontrolled cerebrovascular disease or what the investigator considers Other diseases not included in the group; 3. Patients with a history of bone marrow or organ transplantation; Patients with coagulation dysfunction; 4. Patients with immune deficiency diseases or autoimmune diseases who are treated with immunosuppressive drugs; 5. Central nervous system (CNS) metastatic and/or cancerous meningitis; 6. People who may be allergic to immunotherapy; 7. Drug abuse, clinical or psychological or social factors that affect informed consent or the conduct of the study; 8. Pregnant and lactating women; 9. Participating in other clinical trials; 10. An uncertainty that the investigator believes has an impact on the subject's safety or compliance.