Clinical Research Directory

Inclusion Criteria: 1. Written informed consent 2. Fluency in Dutch (speaking, reading, writing) 3. Age between 60-79 years (at screening) 4. Subjective cognitive decline plus (SCD+), (criteria of Jessen et al.): 4.1 Self-reported worsening of memory; 4.2 Indication of repetitive concerns (worries) associated with SCD; 4.3 With at least one of the following two features present: (i) onset of SCD within the last 5 years; (ii) age at onset ≥60 years of age; 5\. Presence of at least 2 self-reported risk factors for cognitive decline (based on LIBRA criteria): (i) Diabetes mellitus type II (ii) High cholesterol (iii) Hypertension (iv) High BMI (v) Heart disease (vi) Unhealthy diet (lower regular adherence to Mediterranean diet components such as fish, vegetables, olive oil, pasta and red wine) Exclusion Criteria: 1. Current participation in other intervention trials 2. Technologically illiterate (complete incompetence in working with computers, apps, online questionnaires, smartwatches etc.) 3. No internet access from home 4. Clinical diagnosis of ≥1 of the following: * Neurological pathology (e.g. MCI, dementia, multiple sclerosis, Parkinson's disease, epilepsy); * Current malignant disease(s), with or without treatment; * Current psychiatric disorder(s) (e.g. major depressive disorder, bipolar disorder, schizophrenia, anxiety, psychosis, PTSD); * Symptomatic/decompensated cardiovascular disease (e.g. stroke, angina pectoris, heart failure, recent myocardial infarction); * Severe visual impairment or blindness * Hearing or communicative impairment. * Gastrointestinal tract disorder such as irritable bowel syndrome or inflammatory bowel disease (e.g. Crohn's disease or ulcerative colitis). 5. Current or recent (\<6 weeks) use of prebiotic, probiotic, or dietary fibre supplement that may modulate the microbiota, or unwilling to stop the use of supplements during the study 6. Current or recent (\<6 weeks) of algae/phytoplankton supplements such as spirulina or chlorella, or unwilling to stop the use of supplements during the study 7. Use of psychotropic medication (anti-depressants, anti-psychotics) 8. Use of antibiotics in the 3 months before starting the study or planned use during the study 9. Being an employee of the Human Nutrition and Health Division of Wageningen University. 10. Significant cognitive impairment assessed using the Modified Telephone Interview for Cognitive Status battery (TICS-m score \<23) 11. Request to have Apo-E genotype result disclosed 12. Allergies to fish or shellfish 13. Having a contra-indication to MRI scanning including: * Ferromagnetic implants: * Active implantable medical devices such as: insulin pump / medicine pump / neurostimulator; pacemaker / defibrillator; * Other passive implants such as: punctured port-a-cath; synthetic heart valve * Intra-orbital or intra-ocular metallic fragments * Claustrophobia