Clinical Research Directory

Inclusion Criteria: * \- Patients 18-75 years old with ADPKD, defined according to international diagnostic and classification criteria14, treated at Cantonal Hospital Graubünden (KSGR) and the University Hospital Zürich (USZ) independent of baseline treatment with the vasopressin receptor antagonist Tolvaptan * Informed consent as documented by signature Exclusion Criteria: * \- renal replacement therapy or kidney allograft recipient * chronic kidney disease CKD KDIGO Stage G4 (eGFR under 30ml/min/1.73m2) * patients younger 18 years of age * Diabetes mellitus type 1 * recurrent urinary tract infections (UTI) defined as more than 3 infections requiring antibiotic treatment or over 1 requiring hospitalization/year. * Patients with uncontrolled hypertension (defined as ambulatory systolic BP over 180mmHg), liver cirrhosis (Child Pugh B and C) * Patients not able or not willing to stop the following medications during the study period of participation in the trial: * Thiazide diuretics * Carbonic anhydrase inhibitors * Sodium bicarbonate * 1, 25 (OH) vitamin D (calcitriol) * Bisphosphonate, denosumab, teriparatide * Pregnant or lactating women * Known allergy to study drug * Inability to understand and follow the protocol