Clinical Research Directory

Inclusion Criteria: * Patients diagnosed with advanced colorectal cancer or pancreatic cancer who are undergoing treatment with Oxaliplatin-based chemotherapy at Chungnam National University Hospital, including both newly diagnosed and recurrent cases. * Aged 19 years or older. * Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 points. * Expected life expectancy of at least 3 months. * Ability to understand the requirements of the clinical trial and willingness to sign the informed consent form. Exclusion Criteria: * Presence of known brain metastases. * Malignant bowel obstruction requiring surgical intervention. * Uncontrolled, active infections, symptomatic congestive heart failure, unstable angina, cardiac arrhythmias, or any psychiatric/social conditions that may limit compliance with the study requirements. * Partial or complete intestinal obstruction. * Pregnant or lactating women. * Use of antibiotics, antifungals, or antiviral agents on more than one occasion within the past month. * Consumption of probiotics products or fermented milk more than twice within the past month. * Patients with neurological or psychiatric disorders.