Clinical Research Directory

Inclusion Criteria: 1. Female, aged ≥ 18 years and ≤ 75 years old; 2. Breast cancer confirmed by histology or cytology; 3. One of the following two conditions shall be met: a) Operable breast cancer: Recurrent progression during adjuvant therapy; or the time from initial treatment to the onset of disease progression is less than or equal to 2 years; b) Non-operable breast cancer: patients who have changed two line treatment plans within 6 months; 4. Being able to obtain sufficient fresh tissue specimens for organoid establishment through puncture; 5. Expected survival time ≥ 3 months; 6. The patient voluntarily joined this study and signed an informed consent form (ICF), with good compliance and cooperation in follow-up. Exclusion Criteria: 1. Pregnant and lactating women; 2. Patients who have clinically significant (i.e. active) heart disease (such as congestive heart failure, symptomatic coronary artery disease, arrhythmia, etc.) or myocardial infarction within the past 12 months; 3. Individuals with a history of abuse of psychotropic drugs who are unable to quit or have mental disorders; 4. The researchers believe that patients are not suitable for inclusion.