Clinical Research Directory

Inclusion Criteria: * Patients between 20 and 60 years of age with functional constipation of more than 5 years of evolution. Exclusion Criteria: * Taking any type of antibiotic in the last month * Taking prebiotics or probiotics products in the last month. * Taking laxatives in the last month. * Undergoing any medicinal treatment * Pregnancy * Subject with a history of current gastrointestinal pathology or disorder such as: acute colon pathology, acute haemorrhagic colitis, suspected digestive perforation, recent abdominal surgery, severe arterial hypertension, abdominal hernia, colon neoplasia, history of cardiac syncope, renal failure, liver cirrhosis, epilepsy, severe psychiatric illness (psychosis), necrosis due to abdominal irradiation, severe anaemia, severe neurovegetative lability.