Clinical Research Directory

Inclusion Criteria: 1. Fully understand and sign the informed consent form; 2. Age ≥18 years and \<80 years; 3. Good physical condition (WHO performance status score 0-1); 4. Pathologically diagnosed with pelvic malignant tumors and received radiotherapy; 5. Diagnosed with chronic radiation proctitis after at least 6 months of endoscopic examination following the completion of radiotherapy and ineffective conventional treatment; 6. Screening period LENT-SOMA score ≥1; 7. Subjects and their spouses or partners have no plans for conception from screening to 6 months after the end of the trial, no plans for sperm or egg donation, and agree to use effective non-pharmacological contraceptive measures during the trial. Exclusion Criteria: 1. Patients with severe liver or kidney dysfunction during the screening period; 2. Patients with severe congestive heart failure or coronary artery disease during the screening period; 3. Patients with allergic constitution or severe systemic immune diseases; 4. Patients with active gastrointestinal bleeding or acute intestinal obstruction during the screening period; 5. Pregnant patients; 6. Patients with rectal stenosis or fistula formation requiring surgical treatment that limits endoscopic therapy; 7. Patients with a screening period LENT-SOMA score of 4; 8. Patients with tumor recurrence or metastasis; 9. Patients currently participating in other clinical trials at the time of screening or who have not been out of another clinical trial for less than 1 month; 10. Other situations deemed unsuitable for inclusion in this study by the investigator.