Clinical Research Directory

Inclusion Criteria: * Patients aged 18 years and older * Admitted to the intensive care unit with septic shock, defined as an increase in the Sequential Organ Failure Assessment (SOFA) score of at least 2 points due to infection, requiring vasopressor drugs to maintain a mean arterial pressure (MAP) ≥ 65 mmHg, and a lactate level \> 2 mmol/L (18 mg/dL) despite adequate fluid resuscitation * Requiring renal replacement therapy according to consensus indications: * KDIGO stage 3 acute kidney injury with oliguria or anuria persisting for more than 72 hours * Urea \> 40 mmol/L * Plasma potassium \> 5.5 mmol/L despite medical treatment * pH \< 7.15 (pure metabolic acidosis with PaCO2 \< 30 mmHg or mixed acidosis with PaCO2 \> 50 mmHg without the possibility of improving alveolar ventilation) * Acute pulmonary edema secondary to hydrosaline overload resulting in severe hypoxemia (oxygen flow \> 5 L/min or FiO2 \> 50% during mechanical ventilation to maintain SaO2 \> 95%) despite diuretic therapy * Receiving continuous renal replacement therapy with a high-adsorption membrane (oXiris membrane) or a conventional membrane (HF1400 membrane) Exclusion Criteria: * Known history of constitutional thrombopathy (Bernard Soulier disease, Glanzmann thrombasthenia, Gray's syndrome or dense granule disease) * Myelodysplastic or myeloproliferative syndrome * Autoimmune thrombocytopenic purpura * Acute leukemia * Hemorrhagic shock * Platelet transfusion within 7 days prior to inclusion * Antiplatelet therapy with clopidogrel or ticagrelor within 5 days prior to inclusion, prasugrel or dipyridamole within 7 days prior to inclusion * Active HIV infection or hepatitis B or C * Pregnant woman * Not affiliated to a social security system or not benefiting from such a system