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RECRUITING
NCT06442033
NA

Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

Sponsor: Jay Alberts

View on ClinicalTrials.gov

Summary

The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.

Official title: Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2024-08-23

Completion Date

2028-12-31

Last Updated

2025-10-23

Healthy Volunteers

No

Interventions

OTHER

High intensity stationary cycling

All community based exercise sessions are: 3x/week for 40 min, which includes a 5-min warm up \& cool down and a 30-minute main exercise set. Exercise parameters will be set by a neurologically trained physical therapist and will be progressed over time with the ultimate goal of the individual reaching moderate-vigorous exercise. Moderate-vigorous exercise for this project is defined as a cadence of 75+ rpms and a target HR of 60-80% of their age-predicted max

Locations (1)

The Cleveland Clinic

Cleveland, Ohio, United States