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Sleep Modulation to Treat Depression
Sponsor: Christoph Nissen
Summary
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need for new developments. The aim of this study is to extend and further develop a longstanding line of research of using sleep neurophysiology as a 'window to the brain' and treatment development in major depression. Particularly, this project is designed to test the feasibility, efficacy and mechanisms of action of a new sleep-based treatment technology.
Official title: Auditory Closed-loop Modulation of Slow Wave Sleep to Treat Major Depressive Disorder
Key Details
Gender
All
Age Range
30 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-07-22
Completion Date
2026-07
Last Updated
2024-07-23
Healthy Volunteers
Yes
Conditions
Interventions
Auditory closed-loop stimulation
Auditory closed-loop suppression of slow wave sleep
Sham stimulation
No auditory stimulation
Locations (1)
University of Geneva
Geneva, Switzerland