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Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
Sponsor: University of Zurich
Summary
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain after SCI. The functionality of the nociceptive pathway in humans as well as its plastic changes following SCI will be inferred with sophisticated sensory and pain phenotyping using quantitative sensory testing (i.e., psychophysical measures), objective neurophysiological measures of pain processing and the recording of pain-related autonomic responses (i.e., galvanic skin response, cardiovascular measures and pupil dilation). In addition, the interplay between the somatosensory and autonomic nervous system and its association with the development and maintenance of neuropathic pain after SCI will be investigated.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2024-04-17
Completion Date
2030-04-30
Last Updated
2025-12-02
Healthy Volunteers
Yes
Interventions
Neurophysiology
Pain-related evoked potentials and nerve conduction studies
Cardiovascular test
Blood pressure control, orthostatic intolerance test, baro-reflex sensitivity, heart-rate variability
Experimental pain paradigms
Temporal summation of pain, conditioned pain modulation
Quantitative sensory testing
Thermal and mechanical sensory testing
Clinical pain phenotype
Pain drawings, plus and minus signs of pain
Locations (1)
Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland