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Effect of Intravenous Amantadine Sulphate on Disorders of Consciousness
Sponsor: Azienda Sanitaria dell'Alto Adige
Summary
Double-blind, placebo-controlled, crossover ("within subjects") study with an A-B-A-B treatment scheme to investigate the neuromodulatory effects of intravenous amantadine sulphate at a single daily dose of 200 mg in patients with disorders of consciousness (unresponsive wakefulness syndrome and minimally conscious state) by integrating traditional neurobehavioral assessment with spectral analysis of electrocortical activity derived from 64-channel electroencephalography (EEG) recordings.
Official title: Effects of Intravenous Amantadine Sulphate on Brain Dynamics and Neurobehavioral Status in Patients With Disorders of Consciousness
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2018-09-15
Completion Date
2024-09-30
Last Updated
2024-06-14
Healthy Volunteers
Yes
Interventions
Amantadine Sulfate
intravenous amantadine sulphate at a single daily dose of 200 mg or physiological saline (0.9% NaCl solution)
Locations (1)
Hospital of Vipiteno
Sterzing, Bolzano, Italy