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Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
Sponsor: Hasselt University
Summary
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
Official title: The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2023-02-20
Completion Date
2026-09
Last Updated
2025-09-15
Healthy Volunteers
Yes
Conditions
Interventions
Adipose tissue biopsy
From each patient, two biopsies will be taken during surgery; one from the subcutaneous and one from the visceral adipose tissue.
Blood sampling
From each patient, two venous blood samples (citrate, LiHe and EDTA plasma) will be taken before surgery.
Questionnaire
Before bariatric surgery, every patient will fill out questions about general health (physical activity, sedentary behavior, sleeping pattern, ...), physical condition before surgery (nausea, food intake, ...), etc.
Patient phenotyping
Length and weight will be measured to calculate body mass index (BMI). Waist and hip circumference will be assessed, as well as blood pressure (both systolic and diastolic) and heart rate at rest. Body composition will be determined using a bioelectrical impedance analysis (BIA) in the hospital. Medication use and comorbidities (that are allowed within the in-/exclusion criteria) will also be derived from the patient's medical files with patient's permission.
Locations (1)
Ziekenhuis Oost-Limburg
Genk, Limburg, Belgium