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NCT06445088

Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma

Sponsor: Sun Yat-sen University

View on ClinicalTrials.gov

Summary

This clinical study aims to evaluate the diagnostic performance of a new Epstein-Barr virus (EBV) C promoter methylation detection kit. All participants will undergo a series of diagnostic tests including VCA-IgA, EBNA1-IgA, and EBV-DNA assays. Additionally, nasopharyngeal swabs will be analyzed for EBV C promoter methylation. Confirmatory biopsy will be performed on all patients to establish a definitive diagnosis. This comprehensive approach seeks to assess the effectiveness of the methylation detection kit in a clinical setting.

Official title: Evaluation of Diagnostic Performance of a Detection Kit for Epstein-Barr Virus C Promoter Methylation in Nasopharyngeal Carcinoma

Key Details

Gender

All

Age Range

Any - Any

Study Type

OBSERVATIONAL

Enrollment

908

Start Date

2024-05-29

Completion Date

2026-12-31

Last Updated

2024-06-25

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

VCA-IgA, EBNA1-IgA, and EBV-DNA

Detect VCA-IgA, EBNA1-IgA, and EBV-DNA for all participants.

DIAGNOSTIC_TEST

EBV C Promoter Methylation Detection in nasopharyngeal swab samples

Detection of methylation status of Epstein-Barr virus C promoter in human nasopharyngeal swab samples

Locations (5)

Fujian Cancer Hospital

Fuzhou, Fujian, China

Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China

ZhongShan City People's Hospital

Zhongshan, Guangdong, China

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

Wuzhou Red Cross Hospital

Wuzhou, Guangxi, China