Clinical Research Directory

Inclusion Criteria: * Gestational age less or equal to 16 + 6 weeks confirmed via ACOG dating guidelines AND one of the following * 35 years of age or older * Family history of first degree relative with diabetes mellitus * Body Mass Index (BMI) greater than or equal to 30 * Hemoglobin A1c value between 5.9% to 6.4% Exclusion Criteria: * Multiple gestations * Current diagnosis of Type 1 or 2 diabetes mellitus including a diagnosis during this pregnancy * Pre-pregnancy chronic (\>2 weeks) usage of systemic steroids (inhaled and short term usage acceptable) * Planned pregnancy termination * Currently taking or took 3 months prior to conception Metformin * Unable to provide informed consent in English or Spanish * Major fetal anomalies listed below that are known prior to enrollment. Major fetal anomalies: * Congenital diaphragmatic hernia * Congenital cystic adenomatoid malformation * Pleural effustions * Chylothorax * Bronchogenic cyst * Bronchopulmonary sequestration * Anomalous pulmonary venous return * Tricuspid atresia * Mitral atresia * Double right ventricle * Ebstein's malformation * Pulmonary atresia * Hypoplastic left heart syndrome * Aortic coarctation * Fetal arrhythmias * Transposition of the great vessels * Tetrology of Fallot * Double outlet right ventricle * Aortic stenosis * Holoprosencephaly * Anencephaly * Dandy-Walker malformation or variant * Septo-optic dysplasia * Neural tube defect * Vein of Galen aneurysm * Bilateral renal agenesis * Cystic renal disease * Obstructive uropathy * Horseshoe kidney * Megacystis microcolon * Cloacal abnormality * Achondrogenesis * Thanatophoric dysplasia * Thoracic dysplasia * Osteogenesis imperfecta * Short rib polydacyly * Any skeletal defect with suspected small thorax * Hypophosphatemia * Any karyotypic abnormality * Any suspected genetic syndrome * Cleft lip/palate * Micrognathia * Hydrops * Fetal anemia (\<35% on cordocentesis) * Neck mass * Gastroschsis * Omphalocele