Clinical Research Directory

Inclusion Criteria: * Subjects with chronic kidney disease (CKD) on HD 3 times weekly for ≥12 weeks prior to screening who can continue HD without changing its frequency or method * If female, is not pregnant, or nursing. * agrees not to donate sperm or egg after the first dose of investigational product administration until 7 days after the last dose of investigational product, and agrees to use contraceptive method from heterosexual intercourse during the study until 7 days after the last dose of investigational product. * Subjects with a prescription dry body weight between 40 and 100 kg Exclusion Criteria: * Planned to receive a kidney transplant during the study. * Has localised itch restricted to the palms of the hands. * Has pruritus only during the dialysis session * Subjects with severe hepatic impairment (Child-Pugh Class C) or concurrent hepatic cirrhosis. * Subject is receiving ongoing ultraviolet treatment . * Subjects with concurrent malignancy except excised basal cell or squamous cell carcinoma of the skin, or carcinoma in situ that has been excised or resected completely. * Known or suspected history of alcohol or drug abuse/dependence within 12 months prior to screening. * New or change of treatment received for itch within 2 weeks prior to screening.