Clinical Research Directory

Inclusion Criteria: * ASA grade: I or II * Age: ≥18 years * Permanent teeth * Pulp diagnosis: necrosis or previously treated * Diagnosis of periapical tissues: symptomatic apical periodontitis * Teeth sensitive to percussion and/or palpation * Initial PAI: 3-5 * Signed Patient Consent Statement for participation in clinical research Exclusion Criteria: * Subjects that do not meet the inclusion criteria * Pregnant women * Patients who receive corticosteroids and/or have received antibiotics within the previous three months * Patients who report pain in a different area than that of the tooth under investigation * Teeth that cannot be isolated with a rubber dam * Teeth with extensive hard tissue destruction that is not restorable * Teeth with an anatomic peculiarity of the root canal (internal resorption, perforation, displacement of root canal course due to previous endodontic treatment) * Teeth in which the formation of the apex has not been completed * Fractured teeth with periodontal involvement * Teeth with periodontal pocket depth ≥ 4mm or teeth with bone loss at the bifurcation of the roots due to periodontitis * Teeth with loss of periodontal attachment ≥ 5 mm * Teeth with embedded exudate in the session planned for root canal obturation. * Teeth that after completion of the endodontic treatment show underocclusion \>2mm or hyperobstruction \>1mm from the radiographic apex. * Teeth in which permanent restoration has not been completed over time less than one month after endodontic treatment.