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A Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
Summary
The aim of the study is to evaluate the efficacy and safety of SKB264 in combination with pembrolizumab as firstline treatment for patients with PD-L1-positive locally advanced or metastatic non-small cell lung cancer (NSCLC).
Official title: A Randomized, Open-Label, Multicenter Phase III Clinical Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab as First-Line Treatment for PD-L1 Positive Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
406
Start Date
2024-06-07
Completion Date
2026-11
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
SKB264
IV Infusion
Pembrolizumab
IV Infusion
Locations (64)
Hebei University Affiliated Hospital
Baoding, China
Beijing Chest Hospital. Capital Medical University
Beijing, China
Beijing Institute for Cancer Research
Beijing, China
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China
Jilin Cancer Hospital
Changchun, China
The First Hospital of Jilin University
Changchun, China
Hunan Cancer Hospital
Changsha, China
The Second People's Hospital of Hunan Province（Brain Hospital of Hunan Province）
Changsha, China
Xiangya Second Hospital of Central South University
Changsha, China
Chengdu Fifth People's Hospital
Chengdu, China
Sichuan Provincial People's Hospital
Chengdu, China
University of Electronic Science and Technology of China, Sichuan Cancer Hospital and Institute & Cancer, The Second People's Hospital of Sichuan Province
Chengdu, China
West China Hospital of Sichuan University
Chengdu, China
Army Medical Center of PLA (Daping Hospital)
Chongqing, China
Chongqing University Cancer Hospital
Chongqing, China
The Southwest Hospital Of AMU
Chongqing, China
The Second Affiliated Hospital of Dalian Medical University
Dalian, China
Dongguan People's Hospital
Dongguan, China
Fujian Cancer Hospital
Fuzhou, China
Fujian Medical University Union Hospital
Fuzhou, China
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, China
Sun Yat-sen Memorial Hospital Sun Yat-sen University
Guangzhou, China
Sun Yat-sen University Cancer Center
Guangzhou, China
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
Sir Run Run Shaw Hospital (SRRSH)
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
The 2nd Affiliated Hospital of Harbin Medical University
Harbin, China
Anhui Provincial Chest Hospital
Hefei, China
The Second Affiliated Hospital Of Anhui Medical University
Hefei, China
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
Jinan, China
Shandong Provincial Hospital
Jinan, China
The Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital
Kunming, China
Gansu Provincial Cancer Hospital
Lanzhou, China
The First Affiliated Hospital of Henan University of Science & Technology
Luoyang, China
Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China
Mianyang, China
Jiangxi Cancer Hospital
Nanchang, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Jiangsu Province Hospital
Nanjing, China
Guangxi Medical University Cancer Hospital
Nanning, China
People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China
Shanghai Chest Hospital
Shanghai, China
Shanghai East Hospital, Tongji University
Shanghai, China
Shanghai Pulmonary Hospital
Shanghai, China
Zhongshan Hospital of Fudan University
Shanghai, China
Yuebei People's Hospital
Shaoguan, China
China Medical University First Affiliated Hospital
Shenyang, China
Liaoning Cancer Hospital
Shenyang, China
Shengjing Hospital, China Medical University
Shenyang, China
Shanxi Province Cancer Hospital
Taiyuan, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, China
Hubei Cancer Hospital
Wuhan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
The First Affiliated Hospital of XiAn Jiaotong University
Xi'an, China
The Second Affiliated Hospital of XiAn Jiaotong University
Xi'an, China
The First Affiliated Hospital Of Xiamen University
Xiamen, China
Xiangyang Central Hospital
Xiangyang, China
Affiliated Tumor Hospital of Xinjiang Medical University
Xinjiang, China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, China
Subei People's Hospital of Jiangsu province
Yangzhou, China
Yibin Second People's Hospital
Yibin, China
The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital，Henan Academy of Innovations in Medical Science
Zhengzhou, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
The Second Affiliated Hospital Of Zunyi Medical University
Zunyi, China