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An Exploratory Study of Deep Cervical Lymphovenous Bypass (LVB) in Alzheimer's Disease
Sponsor: Affiliated Hospital of Jiangnan University
Summary
The main pathological mechanism of Alzheimer's Disease (AD) is the abnormal deposition of amyloid-beta (Aβ) and tau proteins in the brain. Recent studies indicate that these two proteins are primarily cleared through the glymphatic system-meningeal lymphatic vessels-deep cervical lymphatic vessels pathway. Lymphatic circulation disorders in elderly patients can directly lead to the abnormal deposition of these proteins. Deep cervical lymphovenous bypass can improve lymphatic circulation and effectively treat lymphedema. This project aims to verify the effectiveness of 'deep cervical lymphovenous bypass' in treating AD, offering a new surgical treatment method to improve cognitive impairment and the quality of life for AD patients.
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-05-31
Completion Date
2026-07-01
Last Updated
2024-07-12
Healthy Volunteers
No
Conditions
Interventions
Deep cervical Lymphovenous Bypass
Deep cervical lymph-vein bypass surgery, connecting deep cervical lymph input vein vessel
Locations (1)
Affiliated Hospital of Jiangnan University
Wuxi, Jiangsu, China