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NCT06449846

Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma

Sponsor: Zhujiang Hospital

View on ClinicalTrials.gov

Summary

The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy. At the same time, to explore the relationship among the two methods of predicting recurrence of hepatocellular carcinoma, postoperative adjuvant therapy and postoperative recurrence, this study further confirmed the effectiveness of ctDNA-MRD longitudinal monitoring model in monitoring postoperative recurrence of hepatocellular carcinoma and guiding treatment.

Official title: Compare the Accuracy of Circulating Tumor DNA Longitudinal Monitoring Minimal Residual Disease and Microvascular Invasion Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

OBSERVATIONAL

Enrollment

152

Start Date

2024-06-01

Completion Date

2026-12-31

Last Updated

2024-06-10

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

circulating tumor cell DNA detection

circulating tumor DNA blood sample and tissue specimen for circulating tumor DNA will be done to patient with hepatocellular carcinoma

Locations (4)

Shunde Hospital of Southern Medical University

Foshan, Guangdong, China

The Sixth Affiliated Hospital of South China University of Technology

Foshan, Guangdong, China

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China