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Senescent Endometrial Cells in Patients with Thin Endometrial Lining
Sponsor: Trio Fertility
Summary
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: * Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial biopsy with Pipelle catheter
Official title: Is Thin Endometrial Lining Associated with Senescent Endometrial Cells
Key Details
Gender
FEMALE
Age Range
18 Years - 39 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2024-09-11
Completion Date
2027-06
Last Updated
2024-11-21
Healthy Volunteers
Yes
Interventions
Endometrial Biopsy
An endometrial biopsy is the removal of a small piece of tissue from the endometrium, which is the lining of the uterus. Endometrial biopsies are commonly done to check for the window of implantation, to determine ovulation or for enhancing implantation (procedure called endometrial scratching). For this purpose, we will use a "Pipelle" catheter. This procedure is very common in gynecologic practice and generally considered safe. In most of the cases this procedure is indicated for evaluation of irregular vaginal bleeding, vaginal bleeding in post-menopausal women and for infertility related problems (recurrent implantation failures for example).
Locations (1)
Trio Fertility
Toronto, Ontario, Canada