Clinical Research Directory

Inclusion Criteria: * Man or woman between 18 and 65 years old. * Indication for accelerated conventional crosslinking. * Patient with progressive keratoconus (increase in Kmax of ≥ 0.5 diopters in 3 to 6 months or ≥ 1 diopter in 3 to 12 months with loss of 10 microns on minimum pachymetry in 3 to 12 month). * Patient suffering from keratoconus with a compatible topographic form (Kmax ≥ 47.0 diopters (D) and difference inferior-superior of 1.5 D). * Patient with a minimum corneal thickness greater than 400 microns. * Informed and consenting patient. * Patient physically and mentally capable of completing the post-operative pain assessment self-questionnaire. * Patient having signed the informed consent of the French Ophthalmology Society for crosslinking. * Patient affiliated to a social security system or beneficiary of such a system. Exclusion Criteria: * Woman without effective means of contraception, pregnant or breastfeeding. * Patient who has already benefited from a crosslinking procedure on one of the eyes. * Patient with a history of refractive surgery on one of the eyes. * Patient with an intracorneal ring segment on one of the eyes. * Patient suffering from a serious systemic pathology (autoimmune and/or immunodepressive) * Patient with a psychiatric pathology. * Patient on long-term analgesics and/or corticosteroids. * Indication of crosslinking outside the classic protocol. * Patient with central corneal opacity. * Patient suffering from a severe dry eye syndrome or a neurotrophic keratitis. * Patient with a history of ocular herpes. * Patient with a history of ocular varicella-zoster virus infection. * Patient with glaucoma. * Patient treated with topical cyclosporine in the last 6 months. * Patient deprived of liberty by a judicial or administrative decision. * Patient subject to a legal protection measure or unable to express their consent.