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Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.
Official title: A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
190
Start Date
2025-03-25
Completion Date
2029-08
Last Updated
2025-08-12
Healthy Volunteers
No
Interventions
Vitamin A
Enrolled subjects will receive one observed oral vitamin A dose, prior to their HSCT, in the outpatient clinic or inpatient Bone Marrow Transplant (BMT) floor.
Placebo
Placebo pills containing microcrystalline cellulose will be dispensed in patients who are randomized to the placebo arm.
Locations (3)
Moffitt Cancer Center
Tampa, Florida, United States
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States
The Ohio State University
Columbus, Ohio, United States