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Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.
Official title: Hemodynamic Management Following Acute Traumatic Spinal Cord Injury: A Randomized, Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
228
Start Date
2024-07-03
Completion Date
2026-07-31
Last Updated
2024-12-11
Healthy Volunteers
No
Conditions
Interventions
Mean arterial blood pressure (MAP) goal of ≥65 mmHg
The treatment team will maintain MAP ≥65 mmHg for the first five days following injury.
Mean arterial blood pressure (MAP) goal of 85-90 mmHg
The treatment team will maintain MAP 85-90 mmHg for the first five days following injury.
Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg
The treatment team will maintain SCPP ≥65 mmHg for the first five days following injury.
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States