Clinical Research Directory

Inclusion Criteria: 1. Adult pre-menopausal individuals with regular menstrual cycles (defined as menstrual bleeding every 24 to 38 days) 2. Diagnosed with acute VTE on objective imaging; 3. Within two weeks of starting treatment with therapeutic dose anticoagulation; 4. Planned treatment of at least 3 months of therapeutic dose anticoagulation. 5. Written informed consent in accordance with federal, local and institutional guidelines. Exclusion Criteria: 1. Hypersensitivity or allergy to TXA 2. Active major bleeding other than menstrual bleeding 3. Use of hormonal contraceptives 4. Known history of thrombosis and antiphospholipid syndrome (including those patients that are triple positive for lupus anticoagulant, anticardiolipin antibodies, and anti-beta 2-glycoprotein I antibodies. 5. Known renal insufficiency 6. Pregnant or breastfeeding 7. Use of other thrombotic agents 8. Under 18 years of age 9. Patient is unable to provide informed consent (lacking capacity, language etc)