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Letrozole and Misoprostol for Early Pregnancy Loss Management
Sponsor: University of Pennsylvania
Summary
A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.
Official title: Letrozole and Misoprostol for Early Pregnancy Loss Management: A Prospective Pilot Cohort Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-08-22
Completion Date
2026-07-15
Last Updated
2025-08-05
Healthy Volunteers
No
Interventions
Letrozole
Letrozole 10 mg orally daily for three consecutive days
Misoprostol
Misoprostol 800 mcg vaginally within 24 hours of final letrozole dose
Locations (1)
PEACE / Penn Medicine
Philadelphia, Pennsylvania, United States