Clinical Research Directory

Inclusion Criteria: 1. aged ≥ 18 years, male or female 2. Suffering from end-stage renal disease and planning for ABO blood group incompatible living donor kidney transplantation 3. Vaccinated against Neisseria meningitides (quadrivalent vaccine), Pneumococcus or H. influenzae at least two weeks prior to using eculizumab 4. Be able to understand the informed consent form and willing to comply with the protocol Exclusion Criteria: 1. Previous splenectomy 2. Any active bacterial or other infection 3. Known or suspected hereditary complement deficiency 4. Known hypersensitivity to the treatment drug or any of its excipients 5. History of Neisseria meningitidis 6. Any health condition that the investigator believes may interfere with the patient's participation, pose additional risks to the patient, or confound with the patient's assessment (e.g. severe cardiovascular or pulmonary disease)