Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years old; 2. Pathologically diagnosed as primary peripheral non-small cell lung cancer, preoperative staging suggested clinical staging as T1N0M0, stage IA (including new-onset lung cancer after surgery and multiple primary lung cancer); 3. The ECOG PS score is 0-2; 4. Expected survival ≥6 months; 5. Negative driver gene mutation: driver genes were defined as EGFR, ALK, ROS1, RET; 6. Agree to undergo multimode thermal therapy as initial treatment after being assessed unsuitable for surgery or refusing surgery, and sign informed consent. Exclusion Criteria: 1. Patients with poor cardiopulmonary function or other comorbidities who cannot tolerate multimode thermal therapy; 2. Patients whose chest CT indicated that the lung lesions could not be reached through the chest wall through multimode thermal therapy; 3. Severe liver and kidney function and coagulation function abnormalities, platelet count \<70×109/L; 4. Poor control of malignant pleural effusion; 5. Patients who have received other anti-tumor drugs or have used immune checkpoint inhibitors in the past 6 months; 6. The patient has an uncontrolled disease (including but not limited to active infection, symptomatic congestive heart failure, unstable angina, arrhythmia, mental illness, etc.); 7. Those who have undergone surgical operations or had allogeneic organ transplants within 1 month; 8. Primary immune deficiency or autoimmune diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus, etc.); 9. Pregnant and lactating women; 10. Long-term use of steroid; 11. Other circumstances considered inappropriate for participation in this study.