Clinical Research Directory

Inclusion Criteria: * Legally authorized representative signed informed consent; * Male or female aged 21 years or older; * On mechanical ventilation through orotracheal intubation for no more than 72 hours prior to study enrollment or pending mechanical ventilation through orotracheal intubation; * Predicted to remain on mechanical ventilation for at least 48 hours (≥48 hours) from the time of study enrollment Exclusion Criteria: * Mechanical ventilation initiated longer than 72 hours prior to anticipated enrollment; * Body Mass Index (BMI) \> 40 kg/m²; * Fever of 100.4°C or higher; * Situated in the prone position for 24 hours or longer during mechanical ventilation; * Prognosis of mortality within 72 hours, per the patient's physician; * Hypersensitivity to light; * Use of non-invasive ventilation, Continuous Positive Airway Pressure (CPAP) and/or Bilevel Positive Airway Pressure (BiPAP) device for ≥ 50% of the time over the preceding 6 months; * Tracheostomy; * Any one or more of the following present on both sides of the neck (bilaterally) at the intended treatment site(s): internal jugular (IJ) venous cannulation; incisions, significant bruising; burn(s); notable skin irritation/rash, or other skin condition that may place the subject at risk from harm from the device treatment; * Fracture, external or internal hemorrhage, or at risk of hemorrhage following acute trauma or fracture, or known or potential acute occult bleeding (e.g., gastric ulcer, intestine) in the intended treatment areas; * Metallic device implants or body penetrating metallic devices in the upper body/neck area whose location may interfere with the study device treatment administration. E.g., extracorporeal membrane oxygenation (ECMO) cannula; * Non-removable electrical/electronic device in the upper body/neck area that may interfere with the study device treatment administration, e.g., -implanted pacemaker or cardiac defibrillator; * Cardiogenic or septic shock with ongoing severe hemodynamic instability (according to the American College of Chest Physicians definition (that cannot be stabilized within the 48 hours enrollment period); * Conditions that may limit ultrasonographic assessment of diaphragmatic thickness, e.g., occluding chest drain, pleural effusion, pulmonary consolidation of the lower lobe(s); * Current cancer of any type; * Pregnancy; * Any comorbidity, co-existing condition or illness, or other factor that in the opinion of the study investigator may render the subject unsuitable for participation in the study; * Admission to the ICU within the last 12 months due to respiratory distress/failure; * Two or more admissions to the ICU within the prior 12 months for any reason; * Current participation in another clinical study.