Clinical Research Directory

Key Inclusion Criteria: 1. Undergoing a primary elective unilateral TKA 2. Has a body weight ≤130 kg at screening visit 3. Is judged by the investigator to be in good health based on medical history, physical examination, vital sign measurements, and electrocardiograms (ECG's) performed at screening and/or prior to administration of initial dose of study drug as described in the protocol 4. Is in good health based on laboratory safety testing obtained during the screening period as described in the protocol Key Exclusion Criteria: 1. History of bleeding in the past 6 months prior to dosing requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis 2. History of thromboembolic disease or thrombophilia 3. History of major surgery, including brain, spinal, or ocular, within approximately the past 6 months 4. History of major trauma within approximately the past 6 months prior to dosing 5. Hospitalized (\>24 hours) for any reason within 30 days of the screening visit 6. Has an estimated glomerular filtration rate (GFR) of \<45 mL/min/1.73m\^2 at the screening visit using one of the following formulas: the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration equation, or equivalent equation Note: Other protocol-defined Inclusion/ Exclusion Criteria apply