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RECRUITING
NCT06454955
EARLY_PHASE1

Study on B7-H3 Targeted Affibody Radioligand Probes for PET Imaging of Solid Tumors

Sponsor: Peking University Cancer Hospital & Institute

View on ClinicalTrials.gov

Summary

Based on \[68Ga\]B7H3 Affibody-BCH, this study investigates its radioactive uptake and imaging capabilities in tumor patients, with the aim of establishing a correlation between radioactive uptake and B7-H3 receptor expression. Utilizing whole-body PET technology, the pharmacokinetic dynamics of \[68Ga\]B7H3 Affibody-BCH are examined to ascertain its pharmacological characteristics. Ultimately, this research establishes a framework for pharmacokinetic analysis using whole-body PET.

Official title: Study of B7-H3 Mediated Tumor Immune Response Using a Whole-Body Kinetic Approach in Whole-Body PET

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2024-01-01

Completion Date

2026-11-30

Last Updated

2024-08-23

Healthy Volunteers

Yes

Interventions

DRUG

[68Ga] B7H3 Affibody-BCH

An affibody structure specifically targeting B7H3 was developed based on the B7H3 binding domain, and it was structurally optimized to yield a small molecular agent, B7H3 Affibody-BCH, suitable for nuclear medical diagnostic and therapeutic uses targeting B7H3. By labeling with the radioactive isotope \^68Ga, this agent can be used for PET/CT diagnosis of solid tumors.

Locations (1)

Xiangxi Meng

Beijing, Beijing Municipality, China