Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years old, ≤ 75 years old; 2. Patients clinically diagnosed with Crohn's disease shall refer to the Chinese Guidelines for the Diagnosis and Treatment of Crohn's Disease (Guangzhou, 2023) for diagnostic criteria; 3. Patients receiving treatment with Ustekinumab; 4. Agree to participate in this study and sign an informed consent form. Exclusion Criteria: Participants who meet any of the following criteria are not eligible for inclusion in this study. 1. Patients with ALT or AST exceeding the normal upper limit by more than twice, and TBIL exceeding the normal upper limit by more than twice; 2. Patients with creatinine clearance rate less than 60ml/min; 3. Patients with severe active infections in the intestines or other areas that require the use of antibiotics or antiviral drugs; 4. Patients with intestinal tuberculosis, other chronic intestinal infectious diseases, and intestinal malignant tumors; 5. Pregnant and lactating women; 6. The fasting blood glucose of patients with diabetes or screening period exceeds 7.0mmol/L or glycosylated hemoglobin exceeds 6.5%; 7. Merge patients with severe mental illness, drug use, alcohol abuse, etc. who are unable to cooperate with the study; 8. Have participated in any other clinical research within the first month prior to enrollment; 9. The researcher determined that any other disease or condition is not suitable for patients participating in this study.