Clinical Research Directory

Inclusion Criteria: * Adults with at least one implant in function for a minimum of one year affected by peri-implant mucositis. Exclusion Criteria: 1. Pregnant or lactating women 2. patients unable to understand the treatment protocol and sign informed consent and/or patients younger than 18 years old, 3. medical conditions that prevents an oral examination, 4. incapability to perform oral hygiene measures due to physical or mental disorders, 5. patients with uncontrolled systemic diseases or neoplasms, infection with HIV or hepatitis, cardiovascular disease, blood disorders (e.g. coagulation disorders) and severe osteoporosis, 6. patients who have received systemic antibiotics, corticosteroids, or immunosuppressive therapy within 3 months before periodontal evaluation (baseline), as well as those who chronically use nonsteroidal anti-inflammatory drugs, require antibiotic coverage for dental procedures, and those who are undergoing chronic treatment with medications known to affect periodontal health (such as phenytoin or cyclosporine), 7. alcohol or drug addiction 8. implants with mobility and/or occlusal overload.