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Post-CA Neuroprotection With Magnesium
Sponsor: NYU Langone Health
Summary
The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.
Official title: Neuroprotection Following Cardiac Arrest: A Randomized Control Trial of Magnesium
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
178
Start Date
2025-03-25
Completion Date
2026-06-30
Last Updated
2026-04-07
Healthy Volunteers
No
Interventions
Magnesium Sulfate
4 g of magnesium sulfate intravenously within 2 hours of Return of Spontaneous Circulation (ROSC), followed by a continuous drip (16 g) over 24 hours
Saline
Control subjects will receive an equivalent volume of normal saline intravenously.
Locations (1)
NYU Langone Health
New York, New York, United States