Clinical Research Directory

Inclusion Criteria: 1. Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery; 2. Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)\<6); 3. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital; 4. Time from symptom onset or last known normal to enrollment is less than 24 hours; 5. Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent. Exclusion Criteria: 1. A pre-incident mRS ≥ 1 point before onset; 2. Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism; 3. Intolerance or non-cooperation with magnetic resonance examination; 4. Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases; 5. Pregnancy or lactation; 6. Life expectancy is less than 3 months; 7. Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders).