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RECRUITING
NCT06457230
NA

Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder

Sponsor: Shanghai Mental Health Center

View on ClinicalTrials.gov

Summary

To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.

Official title: Exploring the Mechanisms and Efficacy of Cerebellum-Medial Prefrontal Cortex-Based Paired-Pulse Repetitive Transcranial Magnetic Stimulation for Methamphetamine Use Disorder

Key Details

Gender

MALE

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

90

Start Date

2024-12-24

Completion Date

2026-09

Last Updated

2026-06-24

Healthy Volunteers

Yes

Interventions

DEVICE

Paired Associative Stimulation Targeting the Cerebellar-mPFC

The protocol consisted of 180 pulse trains. Each train contained 5 pulse pairs delivered over 1 second, resulting in a stimulation frequency of 5 Hz. Within each pulse pair, the cerebellum was stimulated first, followed by the mPFC after a 6-ms inter-stimulus interval (ISI). In total, 900 pulse pairs were administered, and a complete intervention session lasted 11 minutes and 57 seconds.

DEVICE

Sham Intervention over cerebellum and mPFC

The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.

DEVICE

Sham stimulation over the cerebellum + real stimulation over the medial prefrontal cortex

Participants in this group will receive sham stimulation over the cerebellum (The coil will be placed vertically over the cerebellum) combined with real stimulation over the medial prefrontal cortex.

Locations (1)

Min Zhao, PhD

Shanghai, Shanghai Municipality, China