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mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism
Sponsor: University of Monastir
Summary
The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are: * Is there a significant association between the rs6313 polymorphism of the HTR2A gene and bruxism? * Is there a significant association between the rs6280 polymorphism of the DRD3 gene and bruxism? Participants will: Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms. Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
169
Start Date
2024-06-02
Completion Date
2024-12-17
Last Updated
2024-06-13
Healthy Volunteers
Yes
Conditions
Interventions
Genetic polymorphism
The biological significance of HTR2A and DRD3 in bruxism remains unclear as molecular analyses, including genetic association studies, have not explored the mRNA expression of genes implicated in bruxism. This study aims to evaluate the influence of genetic polymorphisms affecting DRD3 (rs6280) and HTR2A (rs6313) on bruxism to identify potentially associated genotypes. Additionally, it aims to investigate the expression of HTR2A and DRD3 to elucidate their biological significance in bruxism.