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Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Sponsor: University of Pittsburgh
Summary
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Official title: High-resolution Functional Imaging of Speech-induced Sensory Modulation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-05-27
Completion Date
2028-07
Last Updated
2025-06-13
Healthy Volunteers
Yes
Conditions
Interventions
Neural responses to speech functional localizer
Measuring speech-related brain activity using fMRI during a speech listening task.
Neural responses to silent articulation
Measuring speech-related brain activity using fMRI during a silent articulation task.
Neural responses to self vs. externally generated speech
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Event-related potentials for speech
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Neural responses to induced speech errors
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Neural responses to sensory-motor adaptation
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Speech production behaviors
Behavioral measurements of speech during reading passages and words
Auditory acuity testing
Measurements of auditory acuity during listening tasks.
Neural responses to learning a non-speech auditory motor behavior
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Locations (1)
University of Pittsburgh
Pittsburgh, Pennsylvania, United States