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Intra-Tumoral Vascular Growth Patterns is a Robust Indicator of Adjuvant Therapy Following Liver Resection in HCC
Sponsor: Chen Xiaoping
Summary
Vessels that encapsulate tumor clusters (VETC) is an invasive metastatic factor in HCC independent of the epithelial mesenchyme transition (EMT), and VETC positive patients have a higher rate of postoperative recurrence. However, it is not clear how the surgical prognosis of VETC-positive patients can be improved.
Official title: Intra-Tumoral Vascular Growth Patterns is a Robust Indicator of Adjuvant PD-1 Inhibitors Following Liver Resection in Hepatocellular Carcinoma: A Multicenter Cohort and Multiomics Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
620
Start Date
2019-01-01
Completion Date
2025-04-30
Last Updated
2024-06-17
Healthy Volunteers
No
Interventions
Sintilimab
Patient receives first adjuvant PD-1monoclonal antibody 2-4 weeks postoperatively, 200mg IV over 21 days for 9 cycles.
Lenvatinib
Lenvatinib is initiated orally 2-4 weeks postoperatively for about 6 months.
Locations (1)
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Wuhan, Hubei, China