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CMR Right Ventricular Contractile Reserve Following Lung Resection
Sponsor: Belfast Health and Social Care Trust
Summary
Feasibility study investigating CMR dobutamine stress testing before and after lung resection
Official title: Assessment of Right Ventricular Contractile Reserve Following Lung Resection by Dobutamine Stress Cardiac Magnetic Resonance: a Feasibility Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
42
Start Date
2023-07-21
Completion Date
2024-12
Last Updated
2024-10-03
Healthy Volunteers
Yes
Conditions
Interventions
Dobutamine stress CMR
Dobutamine stress testing will be undertaken in keeping with local departmental clinical guidelines with a graded increase in dobutamine infusion up to a maximum of 10microgram/kg/min. The patients' medications will be managed in keeping with the usual clinical practice and departmental guidelines. At rest and on each graded level of dobutamine infusion we will collect cine loops of the cardiac cycle including a short-axis stack of the ventricles, a four-chamber view and flow imaging perpendicular to the main, left and right pulmonary arteries. Post-processing will be dual reported by blinded observers using the Argus analysis software (Siemens) according to a standardised protocol. A safety report of each CMR scan will be generated by a consultant cardiologist, any abnormalities identified will be referred to the appropriate medical speciality and highlighted to the patient's clinical team.
Cardiac biomarker sample
blood samples will be collected pre-operatively, in recovery, on post-operative days 1 and 2, and at 4-8 weeks post-operatively
Locations (1)
Belfast Health and Social Care Trust
Belfast, Northern Ireland, United Kingdom