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Liposomal Bupivacaine With Dexamethasone for Foot Surgery
Sponsor: Rothman Institute Orthopaedics
Summary
This study aims to understand the ideal formulation to utilize in saphenous nerve and popliteal nerve blocks for foot and ankle procedures. It will examine the use of liposomal bupivacaine alone or liposomal bupivacaine with dexamethasone prior to foot and ankle procedures in peripheral nerve blocks. We will compare liposomal bupivacaine (Exparel) and liposomal bupivacaine (Exparel) combined with dexamethasone to determine if the addition of dexamethasone significantly decreases postoperative narcotic use and prolongs analgesic effects when administered in a popliteal and saphenous block prior to foot and ankle orthopedic procedures.
Official title: Single-Shot Liposomal Bupivacaine vs. Liposomal Bupivacaine Combined With Dexamethasone Prior to Foot and Ankle Procedures: A Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
126
Start Date
2024-06-17
Completion Date
2025-06-30
Last Updated
2024-06-20
Healthy Volunteers
Yes
Interventions
Exparel 266 MG Per 20 ML Injection
20 mL Liposomal bupivacaine (Exparel, 266 mg) will be administered in the popliteal and saphenous block
Bupivacaine Hcl 0.75% Inj
10 mL of 0.75% bupivacaine will be administered in popliteal and saphenous block
Dexamethasone
1 mL of 10 mg Dexamethasone will be administered in the popliteal and saphenous block
Locations (1)
Rothman Orthopaedic Institute
Philadelphia, Pennsylvania, United States