Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years old, gender is not limited; 2. Meet the diagnostic criteria for artificial joint replacement; 3. Initial joint replacement surgery; 4. Voluntary and signed informed consent. Exclusion Criteria: 1. Allergic to self-adhesive silicone rubber waterproof dressing; 2. Patients with severe knee joint infection who cannot undergo artificial joint replacement; 3. Progressive renal insufficiency (stage 4 and above) or glomerular filtration rate less than 30ml/min; 4. periprosthesis infection after multiple joint replacement; 5. Active infection at the site of intravenous or joint injection; 6. long-term use of anticoagulants or antiplatelet drugs due to other diseases; 7. Have sepsis or positive blood culture within the last 30 days; 8. Radiotherapy and chemotherapy are required due to neoplastic diseases; 9. Receiving systemic glucocorticoid therapy (prednisone \> 10mg/ day or equivalent hormone medication); 10. severe immunodeficiency diseases (such as stage 3 HIV, sickle cell anemia, splenectomy, etc.); 11. Have a history of drug abuse; 12. Treatment of bone marrow or other transplants with immunosuppressive drugs; 13. Pregnant, parturient and lactating women; 14. Participating in other clinical trials; 15. Researchers believe that other reasons are not appropriate for clinical trial participants.