Clinical Research Directory

Inclusion Criteria: For women with migraine \- Episodic menstrually-related migraine without aura \> 12 months according to the International Classification of Headache Disorders 3rd Edition (ICHD-3) criteria For women with migraine and healthy women * 18-40 years of age * Weight 50-100 kg * Regular menstruation Exclusion Criteria: For women with migraine * Other primary headache disorders than migraine, except infrequent episodic tension-type headache according to the ICHD-3 criteria * Secondary headache disorders * Headache on the first scan day or 48 hours before the first scan * Absence of the menstruation for the past 12 months * Daily intake of medication of any kind except oral contraceptives * Ingestion of any type of medication later than 4 times the plasma half-life of the substance in question (on the day of the scan), except for oral contraceptives * Intake of coffee, tea or alcohol 12 hours prior to scan days * Fertile women not using safe contraception. Fertile women are defined as women without hysterectomy and \< 2 years postmenopausal women. Safe contraception includes the intrauterine device, oral contraceptive pills, surgical sterilization of the woman, depot progestogen or condoms * Change of hormonal contraceptives for the past 3 months * Perimenstrual syndrome * Pregnant or breastfeeding women * Information or clinical signs of: * Hypertension (systolic blood pressure \> 150 mm Hg and/or diastolic blood pressure \> 100 mm Hg) * Low blood pressure (systolic blood pressure \< 100 mm Hg and/or diastolic blood pressure \< 50 mm Hg) * Cardiovascular diseases of any kind, including cerebrovascular disease * Diabetes * Unregulated mental illness or substance abuse * Illnesses of any kind deemed incompatible by the examining physician for participation in the study * Contraindications to MRI (including metal in the body or claustrophobia) * Do not want to be informed about unexpected pathological findings on the MRI For healthy women * History of any primary headache except infrequent episodic tension-type headache according to the ICHD-3 criteria * First degree family history of primary headache disorders except infrequent episodic tension-type headache according to the ICHD-3 criteria (max five days/month) * Secondary headache disorders * Headache during the menstrual period from 2 days before to 2 days after the first menstrual bleeding day * Headache on the first scan day or 48 hours before the first scan * Absence of the menstruation for the past 12 months * Daily intake of medication of any kind except oral contraceptives * Ingestion of any type of medication later than 4 times the plasma half-life of the substance in question (on the day of the scan), except for oral contraceptives * Intake of coffee, tea or alcohol 12 hours prior to scan days * Fertile women not using safe contraception. Fertile women are defined as women without hysterectomy and \< 2 years postmenopausal women. Safe contraception includes the intrauterine device, oral contraceptive pills, surgical sterilization of the woman, depot progestogen or condoms * Change of hormonal contraceptives for the past 3 months * Pregnant or breastfeeding women * Perimenstrual syndrome * Information or clinical signs of: * Hypertension (systolic blood pressure \> 150 mm Hg and/or diastolic blood pressure \> 100 mm Hg) * Low blood pressure (systolic blood pressure \<100 mm Hg and/or diastolic blood pressure \< 50 mm Hg) Investigation of functional brain features in women with migraine * Cardiovascular diseases of any kind, including cerebrovascular disease. * Diabetes * Unregulated mental illness or substance abuse * Illnesses of any kind deemed incompatible by the examining physician for participation in the study * Contraindications to MRI (including metal in the body or claustrophobia) * Do not want to be informed about unexpected pathological findings on the MRI