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Neuroplasticity Biomarkers in Aphasia
Sponsor: University of Wisconsin, Madison
Summary
Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.
Official title: Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes
Key Details
Gender
All
Age Range
40 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2025-03-17
Completion Date
2029-05-31
Last Updated
2025-10-23
Healthy Volunteers
No
Interventions
Pseudoword learning paradigm task
Pseudoword learning is an experimental learning task by which participants view two novel objects (a target and a foil) and simultaneously hear an audio recording of the pseudoword name of one of the two objects. Participants must choose (via mouse click) which object corresponds to the word presented, immediately after which feedback is provided.
Locations (1)
UW School of Medicine and Public Health
Madison, Wisconsin, United States