Clinical Research Directory

Inclusion Criteria: * patients suffering from septic shock hospitalized in an intensive setting * patients over 18 years and under 80 years of age * patients within 24 hours of clinical diagnosis, and requiring, in this time window, a norepinephrine dosage equal to or greater than 0.25 mcg/kg/min according to the patient's ideal weight (IBW) * patients capable of expressing informed consent to treatment. Exclusion Criteria: * patients in the absence of consent to participate in the study and to the processing of personal and particular data; * patients under 18 years of age or over 80 years of age; * patients who died within the first 24 hours of admission to the ICU; * patients requiring a norepinephrine dosage lower than 0.25 mcg/kg/min in the first 24 hours of hospitalization in the ICU; * patients with recent acute coronary syndrome (within the previous 7 days); * patients with allergy/intolerance to the drugs used in the study or to any component of the study drug including excipients; * pregnant patients; * breastfeeding individuals; * patients who need to start renal replacement treatment within 24 hours of admission to the ICU for dialysis emergencies that cannot be deferred; * patients with a history of end-stage renal failure or already undergoing dialysis treatment (CKD stages 4 and 5, with glomerular filtration \< 30 ml/min); * single kidney patients; * patients with bilateral renal hypoplasia; * patients undergoing kidney transplant; * patients undergoing haemoperfusion with an adsorbent cartridge for bacterial endotoxin.