Clinical Research Directory

Inclusion Criteria: 1. Adult patients aged ≥18 years 2. Admitted to the intensive care unit 3. Acute kidney injury defined by the KDIGO criteria 4. Planned initiation of KRT within 12 hours or the receipt of KRT for AKI for ≤48 hours Exclusion Criteria: 1. Lack of commitment to maintain kidney, pharmacologic or respiratory support at the time of screening, or probable transition to comfort care within 48 hours according to the treating clinician 2. Probable discharge from the ICU within 48 hours according to treating clinician 3. Severe burn injury (\>10% of body surface area) 4. Severe abnormality in serum sodium (\>155 or \<120 mmol/L) 5. Important ongoing fluid losses are present and/or are expected to require continued maintenance IV fluids during the next 48 hours 6. The clinical care team believes that the proposed intervention is inappropriate